The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
نویسندگان
چکیده
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
منابع مشابه
Influenza Virus Multiplication Cycle
Human MxA and mouse Mxl are interferon-induced proteins capable of inhibiting the multiplication of influenza virus. MxA protein is localized in the cytoplasm, whereas Mxl protein accumulates in the nucleus. Taking advantage of stably transfected cell lines that constitutively express either MxA or Mxl protein, we examined the steps at which these proteins block influenza A viruses. In infected...
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